CROSSTALK AND ULTRASENSITIVITY IN PROTEIN DEGRADATION PATHWAYS.

Crosstalk and ultrasensitivity in protein degradation pathways.

Protein turnover is vital to cellular homeostasis.Many proteins are degraded efficiently only after they have been post-translationally "tagged" with ACTIVEWEAR a polyubiquitin chain.Ubiquitylation is a form of Post-Translational Modification (PTM): addition of a ubiquitin to the chain is catalyzed by E3 ligases, and removal of ubiquitin is catalyz

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Filling the Void: An Optimized Polymicrobial Interkingdom Biofilm Model for Assessing Novel Antimicrobial Agents in Endodontic Infection

There is a growing realization that endodontic infections are often polymicrobial, and may contain Candida spp.Despite this understanding, the development of new endodontic irrigants and models of pathogenesis remains limited to mono-species biofilm models and is bacterially focused.The purpose of this study was to develop and optimize an interking

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